10/31/2023 0 Comments High level health omer![]() Association between the XRCC3 T241M polymorphism and risk of cancer: evidence from 157 case-control studies. Gene polymorphisms and chronic obstructive pulmonary disease. The global burden of chronic respiratory disease in adults. 5.ěurney P, Jarvis D, Perez-Padilla R.Lung-Function Trajectories Leading to Chronic Obstructive Pulmonary Disease. Global and regional estimates of COPD prevalence: systematic review and meta-analysis. Global, regional, and national prevalence of, and risk factors for, chronic obstructive pulmonary disease (COPD) in 2019: a systematic review and modelling analysis. 2.Ědeloye D, Song P, Zhu Y, Campbell H, Sheikh A, Rudan I NIHR RESPIRE Global Respiratory Health Unit.Prevalence and attributable health burden of chronic respiratory diseases, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017. GBD Chronic Respiratory Disease Collaborators. Endothelin-1 gene polymorphism may be considered as a predictive genetic factor of COPD in Türkiye. Conclusion: Endotelin-1 gene polymorphism (+134 insA/delA) significantly increased in the patients than healthy ones (p<0,013). Results: In comparison with the healthy group, the COPD group has higher ratio of ET-1 gene (+134 insA/delA) polymorphism (p< 0,001). In this study, for endothelin gene -3A/-4A (-138 insertion/deletion) polymorphism analysis, PCR-RFLP method was used. Allele ratio and genotype distribution, distribution amongst three genotype in the COPD patient and healthy control group was analyzed. In our study, we search for the density of single nucleotide gene polymorphism (+134 insA/delA) in ET-1 gene in the 87 smoking COPD and 89 healthy cases. Methods: This prospective case-control study included 89 patients admitted with COPD and 87 control patients. ![]() In the current studies there being a high ratio of Endotelin-1 (ET-1) in BAL liquid of COPD cases made researchers think ET-1 may have an important role in pathogenesis of COPD. ![]() In addition to many pathogenic mechanisms taking part in inflammatory process, Our study group does research on the relation of COPD with single nucleotide gene polymorphism at ET-1 gene. The most important risk factor is smoking. Abstract Introduction: Chronic Obstructive Pulmonary Disease (COPD) is a common multifactorial disease which has heterogeneous pathogenesis.
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