10/31/2023 0 Comments High level health omer![]() Association between the XRCC3 T241M polymorphism and risk of cancer: evidence from 157 case-control studies. Gene polymorphisms and chronic obstructive pulmonary disease. The global burden of chronic respiratory disease in adults. 5.ěurney P, Jarvis D, Perez-Padilla R.Lung-Function Trajectories Leading to Chronic Obstructive Pulmonary Disease. Global and regional estimates of COPD prevalence: systematic review and meta-analysis. Global, regional, and national prevalence of, and risk factors for, chronic obstructive pulmonary disease (COPD) in 2019: a systematic review and modelling analysis. 2.Ědeloye D, Song P, Zhu Y, Campbell H, Sheikh A, Rudan I NIHR RESPIRE Global Respiratory Health Unit.Prevalence and attributable health burden of chronic respiratory diseases, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017. GBD Chronic Respiratory Disease Collaborators. Endothelin-1 gene polymorphism may be considered as a predictive genetic factor of COPD in Türkiye. Conclusion: Endotelin-1 gene polymorphism (+134 insA/delA) significantly increased in the patients than healthy ones (p<0,013). Results: In comparison with the healthy group, the COPD group has higher ratio of ET-1 gene (+134 insA/delA) polymorphism (p< 0,001). In this study, for endothelin gene -3A/-4A (-138 insertion/deletion) polymorphism analysis, PCR-RFLP method was used. Allele ratio and genotype distribution, distribution amongst three genotype in the COPD patient and healthy control group was analyzed. In our study, we search for the density of single nucleotide gene polymorphism (+134 insA/delA) in ET-1 gene in the 87 smoking COPD and 89 healthy cases. Methods: This prospective case-control study included 89 patients admitted with COPD and 87 control patients. ![]() In the current studies there being a high ratio of Endotelin-1 (ET-1) in BAL liquid of COPD cases made researchers think ET-1 may have an important role in pathogenesis of COPD. ![]() In addition to many pathogenic mechanisms taking part in inflammatory process, Our study group does research on the relation of COPD with single nucleotide gene polymorphism at ET-1 gene. The most important risk factor is smoking. Abstract Introduction: Chronic Obstructive Pulmonary Disease (COPD) is a common multifactorial disease which has heterogeneous pathogenesis.
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10/31/2023 0 Comments Mp4 trimmer ware![]() This online trimmer for MP4 is also equipped with output formats to convert your videos into other video formats. On the other hand, you can define the parts to cut in seconds for precise and accurate editing. In like manner, you can use the markers for cutting or trimming. This free program offers useful video and audio editing functions that include cutting or trimming videos. Supports MP4, AVI, FLAV, MOV, and more video files.Ĭlideo is another online trimmer MP4 file that you should consider using.It does not require downloading anything on your computer.Or, while the video is playing, you can use the current position of the playhead on the video and set it as the position for starting or ending of cutting MP4. ![]() The tool lets select the start and end time by seconds when cutting the video, which is manual. It works well with nearly all web browsers. You can opt for online programs such as Ezgif. Suppose you don't want to download a program for cutting MP4 videos. The best part is it is easy to manipulate that uses a slider to cut and trim video files. You can split, trim, and even merge files with this simple MP4 trimmer for Mac. Aside from being a media player, this also works well as a video cutter allowing you to manipulate your videos. If you are on a Mac and you would like to cut your MP4, QuickTime is a highly recommended program to use.
10/31/2023 0 Comments Pathological complete response her2![]() The aim of the present study is the retrospective evaluation of the predictive and prognostic role of HER2 expression levels in HER2+ BC patients receiving neoadjuvant treatment together with other clinico-pathologic variables as tumor infiltrating lymphocytes (TILs), histologic grade, residual tumor cellularity (RTC). The treatment with anti-HER2 drugs in BC patients is primarily based on HER2 protein overexpression established by immunohistochemistry (IHC) method, while “dual-probe in situ” hybridization (SISH) is used in case of HER2 with equivocal immunohistochemical score (IHC 2+). Identifying accurate and reliable biomarkers to predict response to HER2-targeted therapy in this subtype of BC has become a priority. ![]() Several clinical trials proved that about 25–30% of HER2+ BC patients, treated with trastuzumab, after adjuvant chemotherapy experienced recurrence within 10 years of diagnosis 5, 10 and locoregional or distant recurrence has been identified after dual HER2-targeted neoadjuvant treatment (about 7.1% of cases) 11. Unfortunately, not all HER2+ BC patients have clinical improvement from anti-HER2 therapies. Chemotherapy, combined with dual anti-HER2 therapies, have been used as neoadjuvant treatment in HER2+ BC patients to improve the pathological complete response (pCR) rate 7 which is predictive for more favorable long-term outcome 8, 9. Currently, a combination of sequential chemotherapy and anti-HER2 drug is the landmark for patients with HER2+ BC subtype, both in the neoadjuvant, adjuvant and metastatic setting 6, 7. trastuzumab) have established a considerable upgrade in outcomes of patients affected by HER2+ BC subtype and modified the tumor natural biology 3, 4, 5. HER2 signaling triggers PI3K/AKT and RAS/RAF/MAPK pathways, boosting cell proliferation, growth, invasion, and angiogenesis in tumors 2. HER2 protein overexpression is observed in ~ 15–20% of all invasive breast cancer (BC), and it is associated to high invasiveness and worse prognosis if not properly treated 1. HER2 is a membrane glycoprotein with tyrosine kinase activity and a member of the epidermal growth factor receptor family. The combination of all predictors might offer new options for NACT effectiveness prediction and stratification of HER2+ BC during clinical decision-making. ![]() The immune microenvironment and scarce lymph node involvement have crucial role in clinical outcomes. Increasing TILs concentrations, lower lymph node ratio and lower residual tumor cellularity are associated with a better outcome. HER2 IHC3+ and G3 are poor prognostic factors for HER2+ BC patients, and could be considered in the application of neoadjuvant therapy. HER2 IHC score and laterality emerge as strong predictors of tumoral pCR after NACT from machine learning analysis. Better pCR rate correlate with a high percentage of infiltrating immune cells and right-sided tumors, that reduce distant metastasis and improve survival, but no incidence difference. 93.7% of ypT0 were HER2 IHC3+ BC, 6.3% were HER2 IHC 2+/SISH+ and 86.7% of ypN0 were HER2 IHC3+, the remaining were HER2 IHC2+/SISH+. High tumoral pCR show a scarce mortality rate vs subjects with a lower response. The tumoral pathological complete response (pCR) rate was 40.9%. We evaluate the predictive and prognostic role of HER2 protein/gene expression levels combined with clinico-pathologic features in 154 HER2+ BCs patients who received trastuzumab-based neoadjuvant chemotherapy (NACT). HER2+ breast cancer (BC) is an aggressive subtype genetically and biologically heterogeneous. 10/31/2023 0 Comments Grid instagram postIf your current draft is scheduled to be published after any other existing scheduled posts, this will be reflected in the grid. Your grid will be displayed in reverse chronological order, as it will appear on Instagram when all scheduled posts are published. Hover over the grid to view the scheduled time for future posts. This includes your current draft and any other posts which are scheduled, but not yet published. Posts which have not yet been published will appear slightly faded compared to those which have already been published.
10/31/2023 0 Comments Hybrid crossover![]() Services and parts not specified herein are excluded. Mitsubishi Motors genuine oil and parts only. Includes the following services and parts: 1st service (12-months/12,000 miles) – oil and filter changes, tire rotation, and multi-point inspection 2nd service (24-months/30,000 miles) - oil and filter changes, tire rotation, cabin air filter change, and multi-point inspection 3rd service (24-months/30,000 miles) - oil and filter changes, tire rotation, and multi-point inspection. ⁶ Included on 2024 model-year Mitsubishi Motors vehicles sold in the United States. MMNA reserves the right to limit and/or change available services. Please see your warranty manual for details. Coverage excludes winching of vehicles off road, vehicles disabled in rally racing or other competitive events and vehicles used for commercial purposes, such as police, taxi, route delivery, livery or daily rental services. ⁵ Timed from the date first sold or put into use, whichever is earlier. See retailer for limited warranty and roadside assistance terms and conditions. Subsequent owners receive the balance of the Limited Warranty of 5 years/60,000 miles. ⁴ All coverage terms are from the original in-service date and are applicable only to the original owner of new, retailed models purchased from an authorized Mitsubishi retailer. ³ Outlander PHEV DC fast charging is only available with CHAdeMO charging systems. Actual range and mileage may vary with driving conditions. ![]() Combined fuel economy Electricity + Gasoline of 64 MPGe. ² Electric range of up to 38 miles on a full charge and a combined electricity + gasoline range of 420 miles. See your local Mitsubishi retailer for details. Retailer price, terms and vehicle availability may vary. ![]() Limited availability at participating dealers may require placing an order and could cause a delay in delivery. Excludes destination/handling, tax, title, license, dealer charges, and options. See your participating dealer for details. This offer may not combine with factory cash rebates. Price, terms and vehicle availability may vary. ** Special lease and special APR offers available through Santander Consumer USA, subject to approved credit and insurance. Retailer price, terms, and vehicle availability may vary. Power 2023 award information, visit /awards. 10/30/2023 0 Comments Houston dash![]() Eight months later, the NWSL and the players union's joint investigation revealed Clarkson engaged in emotional misconduct. In April 2022, then-head coach James Clarkson was suspended by the club. Singer said while Laity's abrupt dismissal was due to shortcomings both on and off the field, the move was not related to the mistreatment of players. "Rather than go about the process and the rest of the season, since we did know, we felt it was best to make a timely decision." "I think because this potentially was not the long-term solution, it didn't make any sense in my mind to continue," Singer said during an interview Wednesday afternoon. With four games remaining in the regular season, the team sits in third-to-last place in the standings but still has a chance to reach a second-straight postseason. Under Laity's leadership in 2023, the team has not won an NWSL match since June 3. The move comes amid a brutal stretch of soccer for the Dash, a squad that hosted a NWSL playoff match last season. On behalf of the Club, community, and our team, I want to thank Sam for his dedication and contributions to our organization. "After considerable evaluation as to what is best for the team at this time, we made the decision to make a change. "We have high ambitions and continuously work to build a competitive team that will represent the city at a high level," Dash general manager Alex Singer wrote in a statement. ![]() The most recent headline came Wednesday morning when the Dash fired head coach Sam Laity less than nine months after he was hired as the club's fourth-ever manager. While the Dash has experienced some success, like reaching the National Women's Soccer League playoffs last season, the team also saw some turnover and controversy, especially lately. HOUSTON, Texas (KTRK) - There's only one women's professional soccer team in Texas, and it's here in Houston. The Houston Dash is back on the hunt for a new head coach after dismissing Sam Laity, who was on the job for just a little under nine months. 10/30/2023 0 Comments Margarita city challengeSign up for our Deal of the Day newsletter ![]() If you’re interested in getting a shot of tequila in your morning email, We are the only media property reviewing tequilas andĪnd reviews of other significant voices in the tequila world in one place. Here at Tequila Raiders, we do more than write about current events in tequila. If you’re interested in submitting an appropriately old-school margarita yourself, you can find the submission for the 2023 margarita challenge on the Cointreau website. Having recently watched Drink Master’s elaborately over-the-top margarita episode, we can only imagine what bartenders will have up their sleeves this year.įirst produced in 1875, Cointreau has established itself as perhaps the most recognizable triple sec liquor for use in margaritas. The winner will receive an additional trip for two to France as well as a sponsored budget to take their cocktail on a tour of the world’s best bars.Īccording to the Cointreau website, the evaluation criteria for the margaritas will be 40% technique, 30% ingredients, 20% storytelling and 10% presentation. Once judges sift through the variety of old-timey margaritas, ten finalists will be flown to France for a series of visits and mixology challenges culminating in a final showdown at the historic Angers Mansion. Sames that fateful night, creating a drink based around two ingredients: Cointreau l’Unique and salt.” “Using only equipment available during the era, contest participants must come up with a unique reimagining of the Original Margarita invented by Ms. The conceit is simple for this year’s challenge, contestants must create an awe-inspiring margarita inspired by the cocktail’s eponymous creator, Margaret “Margarita” Sames.Ĭointreau says the that winning cocktail must be worthy of pleasing the “sophisticated palates” of Sames’ party guests on the night it was first invented in 1948. The Cointreau Margarita Challenge is returning for its third year, and bartenders of all calibers have until January 31st to send in their finest concoctions. ![]() The victor of the 2023 international margarita challenge will win a trip to France and a tour of the world’s best bars. 10/30/2023 0 Comments Keybase file sharing![]() In other Zoom news, it admitted to misleading the public with a recent claim of 300 million daily active users. Get the free app for iOS, Mac, Android, Windows, and Linux. Use Keybase for end-to-end encrypted chat messaging, file sharing, and team collaboration. All feedback will be integrated into the final design and eventually be deployed to users. Learn how Keybase Chats, Files, Teams, and Git are secured. Currently, Zoom plans to publish a detailed draft cryptographic design on May 22, followed by hosted discussions where it will share more detail and solicit feedback from industry experts. Zoom says that it believes the system will provide the equivalent or better security than existing consumer end-to-end encrypted messaging platforms. All encryption keys will be "tightly controlled" by the host, who will admit meeting attendees. Only you and kbpbot can access, read, and edit files in this folder. To do so: In your private Keybase folder, create a new folder with the name yourusername,kbpbot. Whether you should remove Keybase.exe depends on your usage, suspicions of malware, and performance issues. For example, let’s say you’d like to publish your website at . Keybase.exe is the main executable file associated with the Keybase application, which provides end-to-end encryption for secure communication and file sharing. The end-to-end encrypted meetings won't support phone bridges, cloud recording, or non-zoom conference room systems. kbpbot is a Keybase bot designed to help you publish your site using a custom domain. In this scenario, logged-in users will generate public cryptographic identities stored in a repository on the Zoom network, which is used to establish trust relationships between meeting attendees. "In the near future," Zoom plans to offer an end-to-end encrypted meeting mode to all paid accounts. ![]() The company also notes that some features widely used by clients, such as support for attendees to call into a phone bridge or use in-room meeting systems offered by other companies, will always require some of the encryption keys to be kept in the cloud. Currently, encryption keys for each meeting are generated by Zoom servers. ![]() The most recent client release, Zoom 5.0, supports encrypting content using industry-standard AES-GCM with 256-bit keys. Zoom currently uses encryption for all its clients, and content is encrypted via each sending device and only decrypted when it reaches the recipient device. The video conferencing platform says that its goal is to provide the most privacy possible for every use case while balancing the needs of users with its commitment to prevent harmful behavior on the platform. The Keybase team will be integrated into the Zoom family to help build end-to-end encryption that reaches the scalability needed for the platform. Keybase launched in 2014 and is a secure messaging and file-sharing service that uses "deep encryption and security expertise." Zoom today announced the acquisition of Keybase, noting that this is part of its 90-day plan to strengthen the security of the video communications platform. Zoom is a video conferencing platform that has seen impressive growth during the coronavirus pandemic as it has been widely adopted by schools and businesses to support people working and learning from home. 10/30/2023 0 Comments Cyberghost vs nordvpn speedNordVPN offers some excellent features like Onion over VPN and a double VPN system, showing that it's a provider that can really flex its muscles when it comes to the subject of security.Īnd both ExpressVPN and NordVPN have two of the best best Android VPN apps available and certified by the ioXt Alliance - a cybersecurity watchdog of sorts, and yet another sign that these two VPNs really take mobile security seriously. ![]() Keeping that sort of work under its own roof is a good sign. ExpressVPN runs its own zero-knowledge, 256-bit encrypted DNS on all its servers. NordVPN and ExpressVPN both tote impressive privacy credentials, with industrial strength AES-256-GCM encryption and Perfect Forward Secrecy (meaning that even if one session is compromised, your next will be protected again through the use of a different key) at their foundation.īoth claim to block DNS leaks, and our tests backed this up. ExpressVPN vs NordVPN: Security and privacy ![]() It's an excellent product and means a free sub that would normally set you back around $60. You'll get a year of unlimited secure cloud backup from BackBlaze when you sign up for a year of ExpressVPN now. Don't forget about NordVPN promo codes that can save you even more.īut ExpressVPN has now brought a freebie to the table. And it often puts special VPN deals in play, like an extra few months or years on top of the usual subscription length. ![]() If you're happy to sign up to two years of NordVPN (which is paid in full upfront) then the service edges things in terms of pricing. Both ExpressVPN and NordVPN offer a 30-day money-back guarantee. That's excellent value, so long as you don't mind committing for double the length of time. The star of the show is NordVPN’s two-year plan, though, which is currently being offered at only $3.29 a month. ExpressVPN’s cheapest is the year-long plan, which currently offers three extra months free, bringing the monthly cost down to only $6.67. Check out the ExpressVPN promo codes currently available to potentially save even more. However, things start to get quite a bit cheaper if you sign up for longer. NordVPN only offers one plan lasting under a year, which is one month for $11.95 or $4.99 per month if you sign up for a year. ExpressVPN vs NordVPN: Plans, pricing and trialsĮxpressVPN opens with a one-month plan priced at $12.95, and that’s knocked down to $9.99 a month if you opt for six months. ![]() And we must say we prefer its simple list of locations compared to Nord's map design - especially when using one of the best mobile VPN apps. It's the little things that swing it Express's way, like having selected, smart and recent locations all showing neatly in the interface. Nord may have the sheer wealth of numbers, but Express pips it with the variety of locations.Īnd we also prefer Express's general user experience.just. From Albania to Vietnam, these two providers have put in the hard yards to deliver their users options all over the globe. ExpressVPN with its huge inviting 'on/off' button, NordVPN with its illustrated map of the world and 'Quick connect' option.Īs you'll see from the spec comparison, you'll not want for server locations. Once installed, both have you logging on to your choice of their vast number of servers within just a few seconds. ExpressVPN: $6.67 (one year) | NordVPN: $3.29 (two years)įrom the moment you install them, it's crystal clear why these are two of the biggest beasts in the world of VPN. ![]() ![]() Your doctor may recommend a mammogram or other test to evaluate your signs and symptoms. If you've been treated for a breast infection but your signs and symptoms persist, contact your doctor. But if the redness does not improve, your doctor may consider more serious causes of your symptoms, such as inflammatory breast cancer. If your symptoms respond to antibiotics, additional testing isn't necessary. It's reasonable and common to be initially treated with antibiotics for a week or more. Inflammatory breast cancer can be easily confused with a breast infection, which is much more common. A breast injury or breast infection (mastitis) may cause redness, swelling and pain. Other more common conditions have signs and symptoms resembling those of inflammatory breast cancer. Make an appointment with your doctor if you notice any signs or symptoms that worry you. Flattening or turning inward of the nippleįor inflammatory breast cancer to be diagnosed, these symptoms must have been present for less than six months.Enlarged lymph nodes under the arm, above the collarbone or below the collarbone.Dimpling or ridges on the skin of the affected breast, similar to an orange peel. ![]() Discoloration, giving the breast a red, purple, pink or bruised appearance.Thickness, heaviness or visible enlargement of one breast.Rapid change in the appearance of one breast, over the course of several weeks.Instead, signs and symptoms of inflammatory breast cancer include: Inflammatory breast cancer doesn't commonly form a lump, as occurs with other forms of breast cancer. |
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